Give me a sign, any sign

Give me a sign, any sign.

For clinical progress to occur in lung cancer, advances must be made in many inter-related areas. Advances in chemoprevention will be most useful if testing is able to identify those at greatest risk of developing lung cancer. Advances in surgical and ablative therapies will be most useful if testing is able to identify lung cancer at the earliest possible stage. Advances in systemic, targeted ...

Natural Selection: Sign, Sign, Everywhere a Sign

Natural selection is an important factor influencing variation in the human genome, but most genetic studies of natural selection have focused on variants with unknown phenotypic associations. This trend is changing. New studies are rapidly revealing the effects of natural selection on genetic variants of known or likely functional importance.

Give Me Another One!

We investigate the complexity of an optimization problem in Boolean propositional logic related to information theory: Given a conjunctive formula over a set of relations, find a satisfying assignment with minimal Hamming distance to a given assignment that satisfies the formula (NearestOtherSolution, NOSol). We present a complete classification with respect to the relations admitted in the for...

Give me FREEDOM or...

Solving the ME/ME/1 queue with state-space methods and the matrix sign function

Matrix exponential (ME) distributions not only include the well-known class of phase-type distributions but also can be used to approximate more general distributions (e.g., deterministic, heavy-tailed, etc.). In this paper, a novel mathematical framework and a numerical algorithm are proposed to calculate the matrix exponential representation for the steady-state waiting time in an ME/ME/1 que...